Phenotypic Composition of Commercial Anti-CD19 CAR T Cells Affects In Vivo Expansion and Disease Response in Patients with Large B-cell Lymphoma.

Chiara Monfrini Federico Stella Vanessa Aragona Martina Magni Silva LjevarCristina VellaEugenio FardellaAnnalisa ChiappellaFrancesca NanettiMartina PennisiAnna DoderoAnna GuidettiPaolo Corradini Cristiana Carniti

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our data indicate that despite the great heterogeneity of Tisa-cel and Axi-cel products, the differentiation status of the infused cells mediates CAR T-cell in vivo proliferation that is necessary for antitumor response.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
electronic health record
cell death
machine learning
single cell
big data
pi k akt
deep learning