Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults.
Joana B PereiraTheresa M HarrisonRenaud La JoieSuzanne L BakerWilliam J JagustPublished in: European journal of nuclear medicine and molecular imaging (2020)
These findings suggest that the spatial patterns of tau in asymptomatic individuals are clinically meaningful and are associated with Aβ, APOE ε2ε3, sex and cognitive decline. These patterns could be used to predict the regional spread of tau and perform in vivo tau staging in older adults.