Alpha-enolase in viral target cells suppresses the human immunodeficiency virus type 1 integration.

Naoki KishimotoKengo YamamotoNozomi IgaChie KiriharaTowa AbeNobutoki TakamuneShogo Misumi

Published in: Retrovirology (2020)

These results indicate that ENO1 in the viral target cells prevents HIV-1 integration. Importantly, ENO1, but not GAPDH, has the bifunctional inhibitory activity against HIV-1 replication. The results provide and new insights into the function of ENO1 as a moonlighting protein in HIV-1 infection.

Keyphrases

human immunodeficiency virus
antiretroviral therapy
hiv infected
hepatitis c virus
induced apoptosis
hiv positive
hiv aids
cell cycle arrest
sars cov
signaling pathway
hiv testing
endoplasmic reticulum stress
men who have sex with men
cell death
mouse model
protein protein
binding protein