Sex Differences in GABAA Signaling in the Periaqueductal Gray Induced by Persistent Inflammation.

Karen J TonsfeldtKatherine L SuchlandKathleen A BeesonJanet D LoweMing-Hua LiSusan L Ingram

Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)

These studies demonstrate that GABA signaling is modulated in the ventrolateral periaqueductal gray by persistent inflammation differently in female and male rats. Our results indicate that antagonists or negative allosteric modulators of GABAA δ receptors may be an effective strategy to alleviate chronic inflammatory pain and promote opioid antinociception, especially in females.

Keyphrases

oxidative stress
chronic pain
small molecule
pain management
neuropathic pain
spinal cord injury