Novel mutations in DNAH17 cause sperm flagellum defects and their influence on ICSI outcome.

Bing SongTianjin YangQunshan ShenYiyuan LiuChao WangGuanjian LiYang GaoYunxia CaoXiaojin He

Published in: Journal of assisted reproduction and genetics (2023)

Loss-of-function mutations in DNAH17 can lead to severe sperm flagellum defects and male infertility. Patients with MMAF-harboring DNAH17 mutations generally have worse pregnancy outcomes following ICSI. ICSI combined with AOA may improve the outcome of assisted reproductive techniques (ARTs) for men with DNAH17 variants.

Keyphrases

pregnancy outcomes
pregnant women
copy number
type diabetes
preterm birth
metabolic syndrome
gene expression
adipose tissue
skeletal muscle
polycystic ovary syndrome