Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis.
Roberta MagliozziOwain William HowellPascal DurrenbergerEleonora AricòRachel JamesCarolina CrucianiCheryl ReevesFederico RoncaroliRichard NicholasRichard ReynoldsPublished in: Journal of neuroinflammation (2019)
We suggest that the inflammatory milieu generated in the subarachnoid space of the multiple sclerosis meninges by infiltrating immune cells leads to increased demyelinating and neurodegenerative pathology in the underlying grey matter due to changes in the balance of TNF signalling.