Association of progressive optic disc tilt with development of retinal nerve fibre layer defect in children with large cup-to-disc ratio.

In this cohort of Korean children with large vCDR, progressive optic disc tilt in the course of myopia progression was associated with higher RNFLD-development risk. This finding suggests that morphological alterations in the ONH during axial elongation might represent an underlying susceptibility to glaucomatous damage in large-vCDR children.