Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-κB signaling pathway.
Thi Thuy Tien VoYinshen WeeYuh-Lien ChenHsin-Chung ChengVo Phuoc TuanI-Ta LeePublished in: Journal of periodontal research (2021)
Surfactin may elicit anti-inflammatory effects against PM-induced oral inflammatory responses.
Keyphrases
- signaling pathway
- pi k akt
- particulate matter
- air pollution
- toll like receptor
- high glucose
- endothelial cells
- cell cycle arrest
- induced apoptosis
- diabetic rats
- inflammatory response
- cell proliferation
- epithelial mesenchymal transition
- immune response
- nuclear factor
- cell death
- drug induced
- heavy metals
- bacillus subtilis
- lps induced
- extracellular matrix