Monoclonal Gammopathy of Undetermined Significance and Associated Cardiovascular Outcomes in a Hospital Setting-A Fresh Perspective.
Ahmad MustafaChapman WeiGhada ArajiMuhammad Rafay Khan NiaziRadu GrovuMitchell WeinbergJames LaffertyPublished in: Current oncology (Toronto, Ont.) (2024)
There is a paucity of data on the cardiovascular implications of monoclonal gammopathy of undetermined significance, especially among hospitalized patients. Our study aimed to investigate the association between MGUS and cardiovascular outcomes in a hospital setting using the National Inpatient Sample database. MGUS patients were sampled using ICD-10 codes. The patients were stratified into two cohorts based on the presence or absence of MGUS. Comorbidities and cardiovascular outcomes were collected using ICD 10 DM codes. CV outcomes were evaluated before and after 1:1 matching for age, gender, and race. Furthermore, a sensitivity analysis was performed on the matched population, which excluded patients with diabetes mellitus, prior myocardial infarction, chronic kidney disease (stages 3-5), dialysis, hypertension, obesity, metabolic syndrome, cancer, antiplatelets, and oral anticoagulant use and was adjusted for smoking, dyslipidemia, and aspirin use to evaluate the cardiovascular outcomes. MGUS patients had more heart failure, atrial fibrillation, venous thromboembolism, aortic aneurysm, aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation, conduction disorder, cor pulmonale, peripheral vascular disease, and acute myocardial infarction. After matching, MGUS was associated with heart failure, atrial fibrillation, venous thromboembolism, aortic stenosis, mitral regurgitation, conduction disorder, cor pulmonale, and peripheral vascular disease. MGUS was linked to a wide spectrum of cardiovascular diseases in an inpatient setting. Further studies are needed to formulate appropriate recommendations for the screening and management of cardiovascular complications in individuals with MGUS.
Keyphrases
- ejection fraction
- end stage renal disease
- aortic stenosis
- chronic kidney disease
- heart failure
- venous thromboembolism
- left ventricular
- atrial fibrillation
- metabolic syndrome
- aortic valve
- peritoneal dialysis
- newly diagnosed
- acute myocardial infarction
- transcatheter aortic valve implantation
- transcatheter aortic valve replacement
- aortic valve replacement
- cardiovascular disease
- direct oral anticoagulants
- insulin resistance
- prognostic factors
- palliative care
- blood pressure
- low dose
- emergency department
- risk factors
- adipose tissue
- skeletal muscle
- young adults
- machine learning
- pulmonary hypertension
- weight loss
- quality improvement
- uric acid
- adverse drug
- oral anticoagulants
- data analysis