Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms.
Sylwia IwańczykTomasz P LehmannArtur CieślewiczArtur RadziemskiKatarzyna MaleszaMichał WrotyńskiPawel Piotr JagodzinskiMarek GrygierMaciej LesiakAleksander AraszkiewiczPublished in: Biomedicines (2021)
The present study aimed to evaluate the plasma concentration of pro and antiangiogenic factors and their role in the pathogenesis of coronary artery abnormal dilation (CAAD). We measured the plasma concentration of matrix metalloproteinase-8 (MMP-8), transforming growth factor beta 1 (TGF-β1), Angiopoietin-2, vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF) using a sandwich ELISA technique in the plasma of patients with coronary artery abnormal dilation (CAAD, Group 1), coronary artery disease (CAD, Group 2), and normal coronary arteries (NCA, Group 3). Patients suffering from CAAD showed significantly higher plasma concentrations of VEGF (p = 0.002) than those from the control group. Both pathological angiogenesis and inflammation appear to be crucial in the pathogenesis of aneurysmal dilatation of the coronary arteries.
Keyphrases
- vascular endothelial growth factor
- coronary artery
- coronary artery disease
- transforming growth factor
- endothelial cells
- pulmonary artery
- end stage renal disease
- epithelial mesenchymal transition
- percutaneous coronary intervention
- coronary artery bypass grafting
- newly diagnosed
- oxidative stress
- ejection fraction
- chronic kidney disease
- aortic stenosis
- type diabetes
- heart failure
- pulmonary hypertension
- peritoneal dialysis
- aortic valve
- atrial fibrillation
- patient reported
- monoclonal antibody