Surgical Management of G3 Gastroenteropancreatic Neuroendocrine Neoplasms: A Systematic Review and Meta-analysis.
Ioannis A ZiogasPanagiotis T TasoudisLuis C BorbonScott K ShermanPatrick J BrehenyChandrikha ChandrasekharanJoseph S DillonAndrew M BellizziJames R HowePublished in: Annals of surgical oncology (2022)
Surgical management of G3 GEP NENs may provide a potential survival benefit in well-selected cases. Further research is needed to define which patients will benefit most from surgical versus nonsurgical management. The current literature is limited by inconsistent reporting of survival outcomes in surgical versus nonsurgical groups, tumor grade, differentiation, primary tumor site, and selection criteria for surgical and nonsurgical management.