Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging.
David E KorenchanJeremy W GordonSukumar SubramaniamRenuka SriramCeline BaligandMark VanCriekingeRobert BokDaniel B VigneronDavid M WilsonPeder E Z LarsonJohn KurhanewiczRobert R FlavellPublished in: Magnetic resonance in medicine (2019)
The novel multi-EPI pulse sequence can boost CO2 imaging signal in hyperpolarized 13 C bicarbonate imaging while introducing minimal pH bias, helping to surmount a major hurdle in hyperpolarized pH imaging.