Development of a comprehensive normal-phase liquid chromatography × size-exclusion chromatography platform with ultraviolet spectroscopy and high-resolution mass spectrometry detection for the chemical characterization of complex polyesters.
Gino GroeneveldAndrea F G GarganoRobert L C VoetenTijmen S BosPaul BuijsenRon A H PetersPeter J SchoenmakersPublished in: Analytica chimica acta (2024)
The presented platform allows characterization of polyesters with varying fractions of carboxyl or hydroxyl end-group functionalities and varying distributions of molecular weight, degree of branching, and chemical compositions. The number-average and weight-average molar masses are obtained in the same analysis. This information cannot be obtained by any one-dimensional technique. The developed NPLC × SEC-UV/HRMS platform is a valuable tool for characterizing polyesters in an industrial setting.
Keyphrases
- high resolution mass spectrometry
- liquid chromatography
- mass spectrometry
- tandem mass spectrometry
- ultra high performance liquid chromatography
- high throughput
- gas chromatography
- simultaneous determination
- high resolution
- high performance liquid chromatography
- solid phase extraction
- heavy metals
- weight loss
- wastewater treatment
- physical activity
- single molecule
- healthcare
- health information
- magnetic resonance imaging
- computed tomography
- real time pcr
- fine needle aspiration
- ultrasound guided
- body weight
- risk assessment
- social media