Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats.
Hazel HuangAli AminianMonique HassanOlivia DanChristopher L AxelrodPhilip R SchauerStacy A BrethauerJohn P KirwanPublished in: Obesity surgery (2020)
Our data demonstrate that sphingolipid balance, and increased AMPK, SIRT1, PGC-1α, and CS protein expression are part of the mechanism that contributes to the remission of diabetes after RYGB surgery.
Keyphrases
- skeletal muscle
- gastric bypass
- roux en y gastric bypass
- minimally invasive
- coronary artery bypass
- insulin resistance
- type diabetes
- weight loss
- oxidative stress
- cardiovascular disease
- obese patients
- ischemia reperfusion injury
- surgical site infection
- electronic health record
- glycemic control
- bariatric surgery
- machine learning
- metabolic syndrome
- rheumatoid arthritis
- protein kinase