Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems.

Assala Al SamadAudrey BethryOlga JanouskovaJérémie CiccioneChristiane WenkJean-Luc CollGilles SubraTomas EtrychFawaz El OmarYoussef BakkourJean CoudaneBenjamin Nottelet

Published in: Macromolecular rapid communications (2017)

Advanced drug delivery systems (DDS) are easily designed following a photoiterative strategy. Multifunctional polymers are obtained by coupling building blocks of interest to an alkynated poly(ε-caprolactone) (PCL) platform via an efficient thiol-yne photoaddition. Fine-tuning over the design is achieved, as illustrated with targeting and enzyme-responsive DDS.

Keyphrases

cancer therapy
drug delivery
high throughput
air pollution
electron transfer
room temperature
image quality
drug release
magnetic resonance imaging
magnetic resonance
computed tomography
single cell
dual energy