A Novel Dual-labeled Peptide for Multimodal Imaging of EGFR with L858R Mutation.

Myoung Hyoun KimSeul-Gi KimDae-Weung Kim

Published in: Current radiopharmaceuticals (2023)

Specific binding of 99mTc STHHYYP-ECGK-TAMRA to L858R-mutated EGFRpositive NCI-H1975 cells and tumors was demonstrated in in vivo and in vitro studies. The results suggest that 99mTc STHHYYP-ECGK-TAMRA is a good candidate agent for dualmodality imaging targeting EGFR with L858R mutation.

Keyphrases

small cell lung cancer
high resolution
epidermal growth factor receptor
tyrosine kinase
induced apoptosis
endoplasmic reticulum stress
pain management
computed tomography
pet imaging
cell proliferation
chronic pain
cell death
transcription factor
binding protein
photodynamic therapy