Naloxone dosing in the era of ultra-potent opioid overdoses: a systematic review.

Jessica MoeJesse GodwinRoy PurssellFiona O'SullivanJeffrey P HauElizabeth PurssellJason CurranMary M Doyle-WatersPenelope M A BrasherJane A BuxtonCorinne M Hohl

Published in: CJEM (2021)

Practitioners have used higher initial doses, and in some cases higher cumulative naloxone doses to reverse toxicity due to presumed fentanyl/ultra-potent opioid exposure compared with other opioids. High-quality comparative naloxone dosing studies assessing effectiveness and safety are needed.

Keyphrases

chronic pain
pain management
high resolution
primary care
anti inflammatory
oxidative stress
general practice
mass spectrometry