Guanfacine Normalizes the Overexpression of Presynaptic α-2A Adrenoceptor Signaling and Ameliorates Neuropathic Pain in a Chronic Animal Model of Type 1 Diabetes.
Neha MunawarJoelle NaderNajat H KhadadahAshraf Al MadhounWaleed Al-AliLinu A VargheseWillias MasochaFahd Al-MullaMilad S BitarPublished in: Pharmaceutics (2022)
Together, these findings demonstrate that guanfacine may function as a potent analgesic and highlight α2-AR, a key component of the descending neuronal autoinhibitory pathway, as a potential therapeutic target in the treatment of diabetic neuropathic pain.