Ensemble learning model for identifying the hallmark genes of NFκB/TNF signaling pathway in cancers.
Yin-Yuan SuYu-Ling LiuHsuan-Cheng HuangChen-Ching LinPublished in: Journal of translational medicine (2023)
In conclusion, our approach enables the discovery of genes in NFκB-regulated pathways in response to TNF and their relevance to carcinogenesis. We successfully categorized these genes into functional groups, providing valuable insights for discovering more precise and targeted cancer therapeutics.
Keyphrases
- signaling pathway
- pi k akt
- genome wide
- rheumatoid arthritis
- small molecule
- bioinformatics analysis
- lps induced
- genome wide identification
- oxidative stress
- nuclear factor
- epithelial mesenchymal transition
- papillary thyroid
- genome wide analysis
- induced apoptosis
- dna methylation
- high throughput
- gene expression
- cell proliferation
- inflammatory response
- convolutional neural network
- toll like receptor
- drug delivery
- childhood cancer