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A possible case of serum sickness after ocrelizumab infusion.

Vanessa F Moreira FerreiraDorlan J KimbroughJames M Stankiewicz
Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2020)
A 41-year-old female diagnosed with multiple sclerosis began ocrelizumab treatment. She received her first treatment course without significant complication. After receiving the first maintenance dose 6 months later, she developed weakness, myalgias, gastrointestinal symptoms, headache, and intermittent fever persisting for 4 weeks. A working diagnosis of serum sickness was determined after excluding other probable entities. She received 3 days of 1 g methylprednisolone intravenously and five plasma exchanges, experiencing gradual improvement. Serum sickness has occurred with monoclonal antibodies including rituximab. This case of possible ocrelizumab-associated serum sickness suggests that clinicians should remain vigilant about this possibility with this medication.
Keyphrases
  • multiple sclerosis
  • palliative care
  • high intensity
  • diffuse large b cell lymphoma
  • combination therapy
  • physical activity
  • electronic health record