Dynamics and survival associations of T cell receptor clusters in patients with pleural mesothelioma treated with immunotherapy.

Aakash P DesaiFarhad KosariMaria DisselhorstJun YinAlireza AgahiTobias PeikertJulia UdellSarah H JohnsonJames SmadbeckStephen MurphyGiannoula KaragougaAlexa McCuneJanet Schaefer-KleinMitesh J BoradJohn ChevilleGeorge VasmatzisPaul BaasAaron S Mansfield

Published in: Journal for immunotherapy of cancer (2023)

We identified two unique TCR clusters that were associated with survival on treatment with ICI in patients with pleural mesothelioma. These clusters may enable approaches for antigen discovery and inform future targets for design of adoptive T cell therapies.

Keyphrases

small molecule
free survival
cell therapy
regulatory t cells
high throughput
binding protein
dendritic cells
immune response
bone marrow
mesenchymal stem cells
replacement therapy