Selective serotonin reuptake inhibitor use and risk of major bleeding during treatment with vitamin K antagonists: results of a cohort study.
Sanne BakkerJ Louise I Burggraaf-van DelftMarieke J H A KruipFelix van der MeerWillem M LijferingNienke van ReinPublished in: Thrombosis and haemostasis (2022)
SSRI use is associated with an increased risk of high INR and might be associated with major bleeding. The risk of a high INR was slightly more elevated for CYP2C9 inhibiting SSRI users, suggesting there might be a pharmacokinetic interaction (by CYP2C9 inhibition) next to a pharmacodynamic effect of SSRIs on platelet activation.
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