Increased peripheral inflammation is associated with structural brain changes and reduced blood flow in virologically controlled people with HIV.

Tricia H BurdoJake A RobinsonSarah A CooleyMandy D SmithJacqueline FlynnKalen J PetersenBrittany NelsonElizabeth WesterhausJulie K WischBeau M Ances

Published in: The Journal of infectious diseases (2023)

We observe that the CD4/CD8 ratio and the number of CD16+ monocytes, which are chronic immune cell markers, are associated with volumetric loss in the brain. Additionally, this study shows a potential new association between plasma sCD14 and CBF.

Keyphrases

blood flow
hiv infected
resting state
white matter
antiretroviral therapy
hiv infected patients
oxidative stress
hiv positive
functional connectivity
hepatitis c virus
human immunodeficiency virus
hiv aids
dendritic cells
cerebral ischemia
peripheral blood
chemotherapy induced
nk cells