In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model.
Aline de Sousa Barbosa Freitas PereiraMaria Laura de Souza LimaArnobio Antonio da Silva-JuniorEmanuell Dos Santos SilvaRaimundo Fernandes de Araújo JúniorAgnes Andrade MartinsJovelina Samara Ferreira AlvesArtur de Santana OliveiraLeandro De Santis FerreiraEmily Cintia Tossi de Araújo CostaGerlane Coelho Bernardo GuerraCaroline Addison Carvalho Xavier de MedeirosGerly A C BritoRenata Ferreira de Carvalho LeitaoAurigena Antunes de AraújoPublished in: Pharmaceutical biology (2022)
The formulation modifies pharmacokinetics parameters such as apparent distribution volume and mean residence time. The PLGA + Met 10 mg/kg had a slower elimination rate compared to Met 100 mg/kg in diabetic rats in a periodontal disease experimental model.