PI3K Abrogation Using Pan-PI3K Inhibitor BKM120 Gives Rise to a Significant Anticancer Effect on AML-Derived KG-1 Cells by Inducing Apoptosis and G2/M Arrest

Soroush SadeghiShadi EsmaeiliAtieh Pourbagheri-SigaroodiAva Safaroghli-Azar

Published in: Turkish journal of haematology : official journal of Turkish Society of Haematology (2020)

Taken together, the results of this study reveal the efficacy of BKM120 as a therapeutic approach for AML; however, further investigations should be undertaken to determine the expediency of this inhibitor.

Keyphrases

cell cycle arrest
acute myeloid leukemia
induced apoptosis
endoplasmic reticulum stress
cell death
pi k akt
genome wide
cell cycle
signaling pathway
cell proliferation