Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes.

Melissa S DeRyckeShanaka GunawardenaJessica R BalcomAngela M PickartLindsey A WaltmanAmy J FrenchShannon McDonnellShaun M RiskaZachary C FogartyMelissa C LarsonSumit MiddhaBruce W EckloffYan W AsmannMatthew J FerberRobert W HaileSteven GallingerMark ClendenningChristophe RostyAung-Ko WinDaniel D BuchananJohn L HopperPolly A NewcombLoic Le MarchandEllen L GoodeNoralane M LindorStephen N Thibodeau

Published in: Molecular genetics & genomic medicine (2017)

Results across case subsets may help prioritize genes for inclusion in clinical gene panel tests and underscore the issue of variants of uncertain significance both in well-characterized genes and those for which limited experience has accumulated.

Keyphrases

genome wide
genome wide identification
copy number
bioinformatics analysis
genome wide analysis
transcription factor
gene expression
peripheral blood
drug delivery