Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes.
Melissa S DeRyckeShanaka GunawardenaJessica R BalcomAngela M PickartLindsey A WaltmanAmy J FrenchShannon McDonnellShaun M RiskaZachary C FogartyMelissa C LarsonSumit MiddhaBruce W EckloffYan W AsmannMatthew J FerberRobert W HaileSteven GallingerMark ClendenningChristophe RostyAung-Ko WinDaniel D BuchananJohn L HopperPolly A NewcombLoic Le MarchandEllen L GoodeNoralane M LindorStephen N ThibodeauPublished in: Molecular genetics & genomic medicine (2017)
Results across case subsets may help prioritize genes for inclusion in clinical gene panel tests and underscore the issue of variants of uncertain significance both in well-characterized genes and those for which limited experience has accumulated.