Biodegradable Magnetic Molecularly Imprinted Anticancer Drug Carrier for the Targeted Delivery of Docetaxel.
Zeeshan AliMuhammad SajidSuryyia ManzoorMuhammad Mahboob AhmadMuhammad Imran KhanNoureddine ElboughdiriMuhammad KashifAbdallah ShanablehWajdi RajhiWael MersniEmin BayraktarSahbi Ben SalemPublished in: ACS omega (2022)
Molecularly imprinted biodegradable polymers are receiving considerable attention in drug delivery due to their ability of targeted recognition and biocompatibility. This study reports the synthesis of a novel fluorescence-active magnetic molecularly imprinted drug carrier (MIDC) using a glucose-based biodegradable cross-linking agent for the delivery of anticancer drug docetaxel. The magnetic molecularly imprinted polymer (MMIP) was characterized through scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy, and vibrating sample magnetometry (VSM). The MMIP presented a magnetization value of 0.0059 emu g -1 and binding capacity of 72 mg g -1 with docetaxel. In vitro and in vivo studies were performed to observe the effectiveness of the MIDC for drug delivery. The cell viability assay suggested that the MMIP did not present toxic effects on healthy cells. The magnetic property of the MMIP allowed quick identification of the drug carrier at the target site by applying the external magnetic field to mice (after 20 min of loading) and taking X-ray images. The novel MMIP-based drug carrier could thus deliver the drug at the target site without affecting the healthy cells.
Keyphrases
- molecularly imprinted
- drug delivery
- solid phase extraction
- electron microscopy
- high resolution
- induced apoptosis
- adverse drug
- type diabetes
- drug induced
- squamous cell carcinoma
- emergency department
- cell cycle arrest
- blood pressure
- locally advanced
- working memory
- metabolic syndrome
- magnetic resonance imaging
- radiation therapy
- adipose tissue
- high throughput
- skeletal muscle
- transcription factor
- dna binding
- electronic health record
- endoplasmic reticulum stress
- high fat diet induced