Distinct Mechanisms of β-Arrestin-Biased Agonist and Blocker of AT1R in Preventing Aortic Aneurysm and Associated Mortality.

Zaira Palomino JaraTerri HarfordKhuraijam Dhanachandra SinghRussell DesnoyerAvinash Kumar Srinivasan Dasarathy Sadashiva S Karnik

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

TRV027-engaged AT1R prevented AA and associated mortality by distinct molecular mechanisms compared with the AT1R blocker, Olmesartan. Developing novel β-arrestin-biased AT1R ligands may yield promising drugs to combat AA.

Keyphrases

aortic aneurysm
cardiovascular events
risk factors
cardiovascular disease
angiotensin ii