Test-Retest Stability of Cerebral 2-Deoxy-2-[18F]Fluoro-D-Glucose ([18F]FDG) Positron Emission Tomography (PET) in Male and Female Rats.
Jürgen W A SijbesmaAren van WaardeDavid Vállez GarcíaHendrikus H BoersmaRiemer H J A SlartRudi A J O DierckxJanine DoorduinPublished in: Molecular imaging and biology (2019)
Based on these data for [18F]FDG, the mixing of sexes in imaging studies of the rodent brain will result in an impaired test-retest stability of PET data and a need for larger group sizes to maintain statistical power in group comparisons. The observed differences between males and females do not indicate any specific gender difference in cerebral metabolism but are related to different levels of non-radioactive glucose in blood plasma during isoflurane anesthesia.
Keyphrases
- positron emission tomography
- computed tomography
- pet ct
- pet imaging
- subarachnoid hemorrhage
- electronic health record
- cerebral ischemia
- big data
- blood glucose
- high resolution
- mental health
- white matter
- resting state
- blood pressure
- brain injury
- mass spectrometry
- metabolic syndrome
- adipose tissue
- cerebral blood flow
- artificial intelligence
- insulin resistance
- drug induced