Chondroitin Sulfate Promotes Interstitial Cell Activation and Calcification in an In Vitro Model of the Aortic Valve.
Sudip DahalJonathan Alejandro BramsenBridget R AlberBruce T MurrayPeter HuangMei-Hsiu ChenGretchen J MahlerPublished in: Cardiovascular engineering and technology (2021)
This study demonstrates a more complete model of aortic valve disease, including endothelial cells, interstitial cells, and a stiff and disease-like ECM. In vitro models of both healthy and diseased valves can be useful for understanding the mechanisms of CAVD pathogenesis and provide a model for testing novel therapeutics.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- aortic valve replacement
- transcatheter aortic valve implantation
- aortic stenosis
- endothelial cells
- induced apoptosis
- single cell
- cell cycle arrest
- chronic kidney disease
- cell therapy
- extracellular matrix
- stem cells
- hyaluronic acid
- vascular endothelial growth factor
- high glucose
- mesenchymal stem cells
- pi k akt