An inflammation resolution-promoting intervention prevents atrial fibrillation due to left-ventricular dysfunction.
Roddy HiramFeng XiongPatrice NaudJiening XiaoDeanna K SosnowskiEwen Le QuilliecArnela SaljicIssam H Abu-TahaMarkus KamlerCharles-Alexandre LeBlancDoa'a G F Al-U'DattMartin G SiroisTerence HebertJean-François TanguayJean Claude TardifDobromir DobrevStanley NattelPublished in: Cardiovascular research (2023)
RvD1 suppressed MI-related atrial arrhythmogenic remodeling. Early-RvD1 had MI-sparing and atrial-remodeling suppressant effects, whereas late-RvD1 attenuated atrial remodeling and AF-promotion without ventricular protection, revealing atrial-protective actions unrelated to ventricular-function changes. These results point to inflammation-resolution promoting compounds as novel cardioprotective interventions with particular interest in attenuating AF-substrate development.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- left ventricular
- heart failure
- oxidative stress
- left atrial appendage
- oral anticoagulants
- direct oral anticoagulants
- percutaneous coronary intervention
- mitral valve
- single molecule
- physical activity
- acute myocardial infarction
- acute coronary syndrome
- hypertrophic cardiomyopathy
- coronary artery disease
- transcatheter aortic valve replacement