Brain metastasis as the first and only metastatic relapse site portends worse survival in patients with advanced HER2 + breast cancer.

Laura NotewareGloria BroadwaterNicole DalalLaura AlderJames E Herndon IiScott FloydWilliam GilesAmanda E D Van SwearingenCarey K AndersSarah L Sammons

Published in: Breast cancer research and treatment (2022)

OS in patients with HER2 + isolated BCBrM was inferior to those with concurrent progressive or stable/responding ECD. Studies investigating initiation of brain-penetrable HER2-targeted therapies earlier in the disease course of isolated HER2 + intracranial relapse patients are warranted.

Keyphrases

free survival
end stage renal disease
resting state
white matter
newly diagnosed
ejection fraction
squamous cell carcinoma
multiple sclerosis
chronic kidney disease
small cell lung cancer
functional connectivity
locally advanced
cerebral ischemia
radiation therapy
rectal cancer
brain injury