Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis.

Maren Stolp AndersenSara Bandres-CigaRegina H ReynoldsJohn HardyMina RytenLynne Krohn Ziv Gan OrInge R HoltmanLasse Pihlstromnull null

Published in: Annals of neurology (2021)

Our results provide further support for the importance of immune mechanisms in Parkinson's disease pathogenesis, highlight microglial dysregulation as a contributing etiological factor, and nominate a targetable microglial gene candidate as a pathogenic player. Immune processes can be modulated by therapy, with potentially important clinical implications for future treatment in Parkinson's disease. ANN NEUROL 2021;89:942-951.

Keyphrases

inflammatory response
neuropathic pain
lipopolysaccharide induced
lps induced
genome wide
gene expression
copy number
combination therapy
genome wide identification
genome wide analysis