Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients.

Patricio AstudilloJenniffer AnguloKarla PinoJoseane Biso de CarvalhoGuilherme Loss de MoraisSebastián PerezAna Tereza Ribeiro de VasconcelosMarcela FerrésMarcelo López-Lastra

Published in: Pediatric research (2019)

SNPs rs12979860 and rs8099917 correlate with the severity of bronchiolitis and display a sex bias, where GG rs8099917 and TT rs12979860 genotypes are associated with a mild disease in girls but not in boys. These findings suggest that innate immunity and female sex links with the outcome of the diseases induced by respiratory viruses, such as RSV.

Keyphrases

respiratory syncytial virus
respiratory tract
gene expression
genetic diversity