CeO 2 -Decorated Metal-Organic Framework for Enhanced Photodynamic Therapy.
Kaixiu ChenXinran SunYingyan LiuYapu YangMin ShiJie YuShusheng ZhangPengfei ShiPublished in: Inorganic chemistry (2022)
Photodynamic therapy (PDT) is quickly developing as a hopeful cancer treatment. However, hypoxic tumors, poor targeting, and photosensitizers (PS) aggregation limited the efficiency of PDT. Here, we report a hyaluronic acid (HA)-modified CeO 2 -nanoparticle-decorated metal-organic framework (PCN-224@CeO 2 -HA) to enhance PDT and achieve targeted treatment. CeO 2 catalyzes H 2 O 2 to produce O 2 to solve hypoxia problems. HA could target the CD44 receptor, which is highly expressed on the tumor cell membranes. The growth of tumor cells 4T1 and MCF-7 was controlled distinctly after being incubated with PCN-224@CeO 2 -HA under laser irradiation, while the survival ability of normal cell LO2 was nearly unchanged. Importantly, PCN-224@CeO 2 -HA could be effectively aggregated within the tumor area after 12 h of injection, and the tumor growth was remarkably inhibited under laser irradiation. PCN-224@CeO 2 -HA presented good biocompatibility and an excellent antitumor effect, providing a new strategy to produce O 2 in situ for enhanced PDT.
Keyphrases
- photodynamic therapy
- metal organic framework
- fluorescence imaging
- hyaluronic acid
- single cell
- stem cells
- reduced graphene oxide
- endothelial cells
- quantum dots
- gold nanoparticles
- radiation induced
- radiation therapy
- mesenchymal stem cells
- mass spectrometry
- ultrasound guided
- breast cancer cells
- drug delivery
- binding protein