The health implications of food and agriculture production are not generally part of the nursing curriculum and yet nurses understand that vulnerable populations, such as farmworkers, may need special attention in terms of health education, disease prevention, and access to mental health and healthcare services. Nurses also learn about the social determinants of health and increasingly are applying this knowledge to health and wellness in their communities. This article will consider the health impacts of the social determinants and both environmental and occupational exposures experienced by farmworkers and the associated implications for the nursing profession. As health professionals one can help to give voice to this often-voiceless population. Working with farmworkers in partnership is key and working with the Migrant Clinicians Network and other advocacy organizations on state and federal policies that will improve working and living conditions for farmworkers and their families is crucial.