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Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/β-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone loss.

Guoju HongXiaoming HeYingshan ShenXiaojun ChenFang YangPeng YangFengxiang PangXiaorui HanWei HeQiu-Shi Wei
Published in: Stem cell research & therapy (2019)
Our study demonstrates that Chrysosplenetin improves osteoblastogenesis of hBMSCs and osteogenesis in estrogen deficiency-induced bone loss by regulating Wnt/β-catenin pathway.
Keyphrases
  • bone loss
  • bone marrow
  • high glucose
  • diabetic rats
  • stem cells
  • cell proliferation
  • mesenchymal stem cells
  • estrogen receptor
  • drug induced
  • oxidative stress
  • replacement therapy
  • smoking cessation