Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients.
Sara BruschiniMatteo PalloccaEleonora SperandioLorenzo D'AmbrosioFrancesca AscenziClaudia De VitisValentina SalvatiAntonella EspositoSimona Di MartinoFrancesca De NicolaFrancesca PaoliniLuigi FattoreGabriele AlessandriniFrancesco FaccioloMaria Laura FoddaiMassimiliano BassiFederico VenutaMichela D'AscanioAlberto RicciAntonio D' AndrilliChristian NapoliLuigi AurisicchioMaurizio FanciulliErino Angelo RendinaGennaro CilibertoRita ManciniPublished in: Journal for immunotherapy of cancer (2022)
Our study reports for the first time a wide characterization of MPEs LUAD microenvironment, highlighting the importance of specific components of the myeloid compartment and opens new perspectives for the rational design of new therapies for metastatic NSCLC.