Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity.

Xanthi MaragkoudakiMatthew NaylorGeorgia PapacleovoulouEmilie StolarczykDouglas ReesJoaquim M PomboShadi Abu-HayyehAnja CzajkaJane K HowardAfshan N MalikCatherine WilliamsonLucilla PostonPaul D Taylor

Published in: International journal of obesity (2005) (2020)

Maternal obesity adversely influences adult offspring energy balance and propensity for obesity, which is ameliorated by maternal PDX treatment with associated changes in gut microbiota composition and skeletal muscle mitochondrial function.

Keyphrases

insulin resistance
weight loss
metabolic syndrome
birth weight
weight gain
skeletal muscle
pregnancy outcomes
high fat diet
type diabetes
high fat diet induced
adipose tissue
bariatric surgery
pregnant women
gestational age
preterm birth
physical activity