[Mechanism of HOXC6 promoting the progression of prostate cancer by activating the SFRP1/Wnt/β-catenin signaling pathway].

Yong-Jun ZhengWen-Min LiLi-Chuan ZhengYan-Feng ZhouJian WangWei-Mu XiaWei-Jing YeJia-Shun Yu

Published in: Zhonghua nan ke xue = National journal of andrology (2024)

HOXC6 is highly expressed in PCa tissues and related to the proliferation, migration and invasiveness of PCa cells. HOXC6 promotes the growth of DU145 and PC-3 cells in PCa by inhibiting the SFRP1/Wnt/β-catenin signaling pathway, and may be a potential target for clinical treatment of PCa.

Keyphrases

prostate cancer
signaling pathway
induced apoptosis
cell proliferation
stem cells
radical prostatectomy
gene expression
cell cycle arrest
risk assessment
oxidative stress
endoplasmic reticulum stress
climate change
combination therapy