Clock Gene Bmal1 Disruption in Vascular Smooth Muscle Cells Worsens Carotid Atherosclerotic Lesions.

Changpo LinLirong XuXiao TangXiaobo LiChao LuQianyun ChengJunhao JiangYang ShenDong YanRuizhe QianWeiguo FuDaqiao Guo

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Bmal1 disruption in VSMCs worsens atherosclerosis by promoting VSMC migration and monocyte transmigration and impairing antioxidant function. Therefore, Bmal1 may be a potential therapeutic target and biomarker of atherosclerosis in the future.

Keyphrases

vascular smooth muscle cells
angiotensin ii
cardiovascular disease
dendritic cells
oxidative stress
genome wide
copy number
current status
gene expression
anti inflammatory
peripheral blood
type diabetes
risk assessment
immune response
climate change
genome wide identification
genome wide analysis