Speech patterns during memory recall relates to early tau burden across adulthood.

Christina B YoungViktorija SmithCody KarjadiSelah-Marie GroganTing Fang Alvin AngPhilip S InselVictor W HendersonMeghan SumnerKathleen L PostonRhoda AuElizabeth C Mormino

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Speech during delayed memory recall relates to tau PET signal across adulthood. Delayed memory recall score was not associated with tau PET signal. Speech shows greater sensitivity to detecting subtle cognitive changes associated with early tau accumulation. Our cohort spans adulthood, while most PET imaging studies focus on older adults.

Keyphrases

pet imaging
cerebrospinal fluid
working memory
positron emission tomography
depressive symptoms
computed tomography
early life
pet ct
hearing loss
risk factors