Co-clinical study of [fam-] trastuzumab deruxtecan (DS8201a) in patient-derived xenograft models of uterine carcinosarcoma and its association with clinical efficacy.

Shigehiro Yagishita Tadaaki Nishikawa Hiroshi Yoshida Daisuke Shintani Sho Sato Maiko Miwa Mikiko Suzuki Masanori Yasuda Yusuke Ogitani Takahiro Jikoh Kan Yonemori Kosei Hasegawa Akinobu Hamada

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

We successfully performed a co-clinical study of T-DXd in HER2-expressing UCS, along with the STATICE trial. Our PDX models can predict clinical efficacy and serve as an effective preclinical evaluation platform.

Keyphrases

double blind
clinical trial
phase iii
high throughput
study protocol
phase ii
metastatic breast cancer
stem cells
single cell