Establishment of particulate matter-induced lung injury model in mouse.

Se Yong ParkKyu Sup AnBuhyun LeeJu-Hee KangHyun Jin JungMin Woo KimHyeon Yeol RyuKyu-Suk ShimKi Taek NamYeo Sung YoonSeung Hyun Oh

Published in: Laboratory animal research (2021)

In this study, we established a PM-induced lung injury model to examine the lung damage induced by PM. Based on our results, repeated exposures of PM are necessary to induce lung inflammation by PM alone. PM challenge, in the presence of underlying diseases such as asthma, can also be an appropriate model for studying the health effect of PM.

Keyphrases

particulate matter
air pollution
lung function
oxidative stress
polycyclic aromatic hydrocarbons
diabetic rats
high glucose
healthcare
heavy metals
chronic obstructive pulmonary disease
mental health
drug induced
water soluble
endothelial cells
risk assessment
health information
health promotion