α4β7 integrin-dependent adhesion of T cells to MAdCAM-1 is blocked by vedolizumab in patients with chronic refractory pouchitis.

Michaela MeldeTanja Martina MüllerInes SchneiderCarol-Immanuel GeppertLaura MühlLaura BesendorfClarissa AllnerEmily BeckerImke AtreyaFrancesco VitaliGisela FeltenMarkus F NeurathSebastian Zundler

Published in: Therapeutic advances in gastroenterology (2021)

Our data suggest that T cell trafficking seems to be important for the pathogenesis of pouchitis and support the therapeutic use of vedolizumab. Integrin function might serve as a biomarker to predict response to vedolizumab.

Keyphrases

ulcerative colitis
patients with inflammatory bowel disease
cell migration
cell adhesion
electronic health record
big data
escherichia coli
machine learning
data analysis
artificial intelligence