Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts.

Yahaya A YaboPilar M Moreno-SanchezYolanda Pires-AfonsoTony KaomaBakhtiyor NosirovAndrea ScafidiLuca ErminiAnuja LipsaAnaïs OudinDimitrios KyriakisKamil GrzybSuresh K PoovathingalAurélie PoliArnaud MullerReka TothBarbara KlinkGuy BerchemChristophe BertholdFrank HertelMichel MittelbronnDieter H HeilandAlexander SkupinPetr V NazarovSimone P NiclouAlessandro MichelucciAnna Golebiewska

Published in: Genome medicine (2024)

Our data provide novel insights into the phenotypic adaptation of the heterogeneous TME instructed by GBM tumors. We show the key role of microglial phenotypic states in supporting GBM tumor growth and response to treatment. Our data place PDOXs as relevant models to assess the functionality of the TME and changes in the GBM ecosystem upon treatment.

Keyphrases

dendritic cells
electronic health record
big data
case report
machine learning
regulatory t cells
deep learning
risk assessment
artificial intelligence
data analysis
smoking cessation