A high-throughput screen identifies RNA binding proteins that affect fertility in Caenorhabditis elegans and reveals a functional relationship between ADR-2 and SQD-1.

Emily A ErdmannMelanie ForbesMargaret BeckerSarina PerezMary SkellyHeather A Hundley

Published in: bioRxiv : the preprint server for biology (2023)

. Twenty-three regulators of these important reproductive steps were identified, including 7 novel regulators. This screen also revealed a genetic interaction between two RNA binding proteins, SQD-1 and ADR-2, which impacts germline gene expression, oogenesis, and fertility.

Keyphrases

high throughput
gene expression
single cell
genome wide
adverse drug
transcription factor
dna methylation
childhood cancer
nucleic acid
dna repair
copy number
emergency department
young adults