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hP-MSCs attenuate severe acute pancreatitis in mice via inhibiting NLRP3 inflammasome-mediated acinar cell pyroptosis.

Shuang LyuShuirong LiuXin GuoYaolei ZhangZhongyu LiuShan ShiWenya LiJuan PeiYonghong FanHongyu Sun
Published in: Apoptosis : an international journal on programmed cell death (2024)
Our study demonstrates the regularity and important role of acinar cell pyroptosis during SAP. hP-MSCs attenuate inflammation and inhibit acinar cell pyroptosis via suppressing NLRP3 inflammasome activation, thereby exerting a protective effect against SAP.
Keyphrases
  • nlrp inflammasome
  • single cell
  • cell therapy
  • mesenchymal stem cells
  • signaling pathway
  • oxidative stress
  • type diabetes
  • adipose tissue
  • high fat diet induced