High prevalence of HIV-1 transmitted drug-resistance mutations from proviral DNA massively parallel sequencing data of therapy-naïve chronically infected Brazilian blood donors.
Rodrigo PessôaSabri Saeed SanabaniPublished in: PloS one (2017)
Our findings revealed a high prevalence of TDRM found in this group, as the use of MPS drastically increased the detection of these mutations. Sequencing proviral DNA provided additional information about TDRM, which may impact treatment decisions. The overall results emphasize the importance of continuous monitoring.
Keyphrases
- single cell
- circulating tumor
- cell free
- single molecule
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- electronic health record
- nucleic acid
- label free
- circulating tumor cells
- combination therapy
- replacement therapy
- real time pcr
- deep learning
- south africa
- smoking cessation