In vivo analgesic, anti-inflammatory, and sedative activity and a molecular docking study of dinaphthodiospyrol G isolated from Diospyros lotus.

Abdur RaufTareq Abu-IzneidFahad A AlhumaydhiNaveed MuhammadAbdullah S M AljohaniSaima NazSaud BawazeerAbdul WadoodMohammad S Mubarak

Published in: BMC complementary medicine and therapies (2020)

Compound 1 exhibited remarkable analgesic, anti-inflammatory, and sedative activities. These findings strongly justify the traditional use of D. lotus in the treatment of inflammation, pain, and insomnia.

Keyphrases

anti inflammatory
molecular docking
neuropathic pain
molecular dynamics simulations
oxidative stress
chronic pain
spinal cord injury
sleep quality
replacement therapy